What Are Polynucleotides and Why Is Everyone Talking About Them?
In recent years, a clear trend has emerged in the aesthetic world: a shift from synthetic fillers toward biological materials that encourage the skin to regenerate itself. At the center of this trend stands one remarkable ingredient — polynucleotides, better known as Salmon DNA.
Polynucleotides are short DNA fragments derived from marine sources, typically salmon. Their structure is remarkably similar to natural molecules found in the human body, which is why the skin responds to them so effectively. This biological material stimulates cell regeneration, improves texture, and supports repair — all without adding volume or altering facial features.
The treatment is becoming extremely popular among leading aesthetic physicians worldwide because it gives the skin exactly what it needs to recover from the inside out, naturally and sustainably.
How Do Polynucleotides Work?
To understand their power, it helps to know the role of fibroblasts — the cells responsible for producing collagen and elastin. With age, fibroblast activity slows, leading to skin that looks dull, tired, and less elastic.
This is where polynucleotides come in:
They create a natural healing environment in the tissue, stimulate fibroblast activity, improve the extracellular matrix, and enhance the production of new collagen and elastin. They also help calm inflammation, increase microcirculation, and speed up skin recovery.
The result isn’t an instant “filler look.” It’s genuine skin quality restoration.
Who Is a Good Candidate for Polynucleotide Treatment?
This treatment suits a wide range of skin types and concerns. Some of the people who benefit most include:
1. Dull or tired-looking skin
Individuals who feel their skin has lost its glow, developed fine lines, or simply looks dehydrated.
2. Mature skin
Age isn’t a condition, but it slows biological processes. Polynucleotides give the cells a renewed boost.
3. Post-laser or microneedling recovery
The material accelerates healing, reduces inflammation, and supports faster regeneration.
4. Under-eye rejuvenation
Highly effective for the delicate under-eye area, helping with thin skin, fine lines, hollowness, and fatigue.
5. Combination with PRP or PRF
When used together, they enhance one another, providing a stronger regenerative effect. At PRPClinic, this combination is frequently used in advanced protocols.
When Will You See Results?
This is a treatment people love not because you immediately see it, but because you feel it.
The improvement develops gradually through natural biological processes:
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Immediately after treatment: the skin appears fresh, hydrated, and more radiant.
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About two weeks later: improved smoothness, elasticity, and uniformity.
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After six to eight weeks: collagen production increases and the deeper changes begin.
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After three to four sessions: a visible, meaningful improvement in texture and skin quality.
The most natural results appear when you allow the skin time to heal and regenerate on its own.
Polynucleotides for Hair — Does It Work?
Yes. Especially when combined with PRP or iPRF.
These DNA fragments support the scalp tissue, improve the biological environment around the follicles, reduce inflammation, support absorption, and help thicken existing hair fibers.
It’s not a replacement for hair-restoration treatments, but it significantly enhances their effectiveness. The approach is supported by clinical research.
The Treatment Process at PRPClinic
At PRPClinic, there is no “standard treatment.” Every patient receives a fully tailored plan.
1. Personal assessment
A detailed evaluation of skin condition, sun damage, fine lines, tissue quality, and treatment goals.
2. Customized protocol
Determining dosage, injection depth, treatment intervals, and whether to combine PRP or PRF.
3. The treatment itself
Precise and gentle injections, usually placed within the dermal layer. The procedure is quick, requires minimal downtime, and is suitable for all skin types.
4. Follow-up and maintenance
Repeat evaluation, before/after photos, and maintenance sessions every few months according to individual needs.
Key Benefits of Polynucleotides
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Completely natural appearance with no added volume
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Minimal side effects
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Safe even for delicate areas such as the under-eyes and neck
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Excellent synergy with biological treatments like PRP and PRF
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High safety profile and very low risk of sensitivities
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Improves true skin quality rather than masking issues
Is It Safe?
Polynucleotides are considered one of the safest biological treatments in modern aesthetic medicine. Most patients experience only mild redness or slight swelling that fades within hours to a day.
People with severe fish allergies should inform us beforehand. In such cases, we perform a personalized assessment to ensure safety.
Why Choose PRPClinic?
Our extensive experience with biological treatments: PRP, iPRF, CGF, PRGF, and exosomes — allows us to design protocols that deliver real results, not just “another injection.”
We focus on:
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Physician-only treatments
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Advanced equipment and authentic materials
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Gentle, modern injection techniques
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Individualized treatment plans, never generic packages
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Natural results that enhance your features rather than change them
The outcome is simple: your skin, at its very best.
In Conclusion: Polynucleotides Are the Future of Skin Regeneration
If you’re looking for a real improvement in skin quality — without altering facial structure, without added volume, and without an artificial look — polynucleotide treatment is one of the smartest choices available today.
At PRPClinic, we perform this treatment at the highest medical standard, with professional guidance and a fully personalized plan to achieve natural, long-lasting, and truly beautiful results.